Reproductive Immunology Clinics in Canada
Reproductive immunology investigates whether immune system factors — such as elevated natural killer (NK) cells, autoimmune antibodies, or thrombophilias — are contributing to recurrent pregnancy loss, unexplained IVF failure, or implantation failure. The field is still evolving and not all reproductive endocrinologists agree on testing protocols or treatments. We list 19 Canadian fertility clinics that offer reproductive immunology workups and immune-related treatments such as intralipid infusions, IVIG, low-molecular-weight heparin, and steroid protocols. Patients exploring this path should expect an in-depth conversation with their physician about which tests are evidence-supported for their specific situation.
What to look for
- Specialist on-site or referral pathway to a reproductive immunologist
- Clear discussion of which tests have strong evidence vs. controversial use
- Experience treating recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF)
- Collaboration with hematology when thrombophilia is suspected
- Transparent pricing — many immune treatments are not OHIP-covered
19 Reproductive Immunology clinics in Canada
Frequently Asked Questions
Is reproductive immunology covered by provincial health plans?▼
Most reproductive immunology testing and treatments are not publicly covered. Some bloodwork may be covered if ordered for a recognized clinical indication, but specialty panels and treatments like intralipids or IVIG are usually paid out-of-pocket.
When should I consider reproductive immunology testing?▼
Most clinics consider testing after recurrent pregnancy loss (typically 2+ losses), repeated IVF implantation failure with good-quality embryos, or unexplained infertility despite a thorough standard workup.
Are reproductive immunology treatments evidence-based?▼
Some treatments (like low-dose aspirin and heparin for diagnosed antiphospholipid syndrome) have strong evidence. Others (intralipids, IVIG for elevated NK cells) remain debated. A good specialist will discuss the strength of evidence for each option.
What does reproductive immunology testing typically include?▼
Workups commonly include thrombophilia panels, antiphospholipid antibody testing, NK cell assays, thyroid antibodies, and immune subset profiling. Specifics vary by clinic.
How long does an immunology workup take?▼
Initial bloodwork results typically come back in 2 to 4 weeks. Some specialty assays sent to US labs can take 4 to 8 weeks.
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